Nucleoporins in Cancer: Functional Roles and Therapeutic Opportunities
Cet article examine comment la dérégulation des nucléoporines contribue à l'initiation et à la progression tumorales et ouvre la voie à des thérapies anticancéreuses innovantes (colles moléculaires induisant la dégradation sélective des nucléoporines, inhibition pharmacologique du transport nucléocytoplasmique et inhibition de la signalisation épigénomique/transcriptomique régulée par le complexe du pore nucléaire)
The nuclear pore complex (NPC) and its building-block proteins, nucleoporins (NUP), play fundamental roles in maintaining cellular fitness by regulating nucleocytoplasmic transport, chromatin and transcriptional activity, and genome stability. These core biological processes are critical for cancer cells, and thus, tumor-driven co-option of NUP-regulated functions has emerged as an important mechanism contributing to the pathogenesis of multiple malignancies. This review discusses how NUP dysregulation mechanistically contributes to tumor initiation and progression and how these insights open opportunities for innovative anticancer therapies, including using clinical-grade molecular glues that induce selective NUP degradation and pharmacologically inhibiting NPC-regulated epigenomic/transcriptomic signaling and nucleocytoplasmic transport.
Cancer Discovery , résumé, 2026