Obesity Accelerates Multiple Myeloma Progression in Certain Mouse Models and in Humans
Menée à l'aide de données cliniques et de modèles murins de myélome multiple, cette étude démontre que l'obésité accélère la progression tumorale
Obesity is associated with an increased risk of developing multiple myeloma; however, the underlying mechanisms are unknown. We demonstrated that obesity-accelerated multiple myeloma is coupled with immune disruptions in mice and that gene expression is altered in myeloma cells from patients with obesity, further implicating obesity as a critical modifier for prevention.
Cancer Prevention Research , résumé, 2026