FAK to the Rescue: Activated Stroma Promotes a “Safe Haven” for BRAF-Mutant Melanoma Cells by Inducing FAK Signaling
Menée à l'aide de techniques d'imagerie intravitale, cette étude met en évidence des mécanismes par lesquels, de façon paradoxale, un inhibiteur de BRAF (PLX4720) induit, dans le micro-environnement des cellules de mélanome, l'activation de fibroblastes associés aux tumeurs favorisant la résistance thérapeutique
Perhaps the most pressing need in cancer therapeutics is to understand drug resistance. In this issue of Cancer Cell, Hirata and colleagues show that melanoma-associated fibroblasts can drive resistance to the BRAF inhibitor PLX4720 by stimulating matrix production/remodeling, and, consequently, survival signaling in melanoma cells via
β1-integrin, Src, and FAK.
Cancer Cell , commentaire, 2014