Clinical implications of neoepitope landscapes for adult and pediatric cancers
A partir de données portant sur 540 génomes et transcriptomes tumoraux issus de l'analyse d'échantillons prélevés sur des patients pédiatriques atteints d'un cancer, cette étude dresse le catalogue des néoépitopes associés aux anomalies somatiques (mutations et fusions de gènes)
Many immunotherapies rely on the presence of neoepitopes derived from somatic mutations that lead to altered peptide sequences. Several studies have now analyzed the neoepitope landscape of different cancer subtypes, predominantly for adult samples, which tend to feature significantly higher mutational burden. However, a new report publishing the first comprehensive analysis of the pediatric neoepitope landscape suggests that immunotherapies could also hold promise for pediatric cancers.