The Impact of Older Age at Diagnosis on Wilms Tumor Characteristics and Patient Outcomes: A Children’s Oncology Group Study
Menée à partir de données portant sur 4 100 patients atteints d'une tumeur de Wilms diagnostiquée entre 2006 et 2019, cette étude examine les caractéristiques tumorales et les résultats thérapeutiques en fonction de l'âge au diagnostic (âge standard : âge médian au diagnostic d'environ 3,4 ans ; âge plus avancé : âge médian au diagnostic d'environ 13 ans)
Wilms tumor (WT) is the most common primary renal malignancy in children, with peak incidence occurring around 3 years of age and >90% of cases diagnosed before 7 years of age.1–5 Less commonly, WT can occur in older-age patients, with some case reports even in later adulthood.2,6–8 Patients presenting in adolescence and adulthood are estimated to account for 3% of all WT cases, although older-age cases may be underrepresented because data collection relies largely on providers who primarily treat children.3–7,9,10 As no detailed prospective multi-institutional collaborative trials have meaningfully studied this older-age WT patient group, significant knowledge gaps remain.
Journal of the National Comprehensive Cancer Network , article en libre accès, 2026