Creating Outdoor Air Pollution Exposome Metrics for Assessing Breast and Lung Cancer Risks in the United States
Menée notamment à l'aide de données américaines portant sur les concentrations de polluants atmosphériques de référence estimées, cette étude présente de nouveaux indicateurs qui pourront être utilisés pour évaluer le risque de cancer du sein et du poumon associé spécifiquement à l'exposome de la pollution atmosphérique
Air pollution (AP) is a known cause of lung cancer; growing evidence links AP with breast cancer risk. Many epidemiologic studies analyze particulate matter with diameter equal or smaller than 2.5 microns (PM2.5), although AP is a complex mixture of many pollutants. New metrics are necessary to fully represent the carcinogenic constituents of AP. Therefore, we aimed to develop cancer-specific metrics to determine where and what types of AP drive incident cancers.We combined databases of AP across the continental United States in 2005 to 2020, including the Risk-Screening Environmental Indicators (RSEI) model and Center for Air, Climate, and Energy Solutions (CACES) land-use regression–estimated concentrations of criteria air pollutants (CAP). We joined AP concentrations at census tracts and employed meta-analytic cancer-specific risk estimates to weight the CAP and produce a set of combined metrics [AP for breast cancer (APBC) and AP for lung cancer (APLC)] from numerous sources.APBC and APLC exhibited positive skew, with certain tracts having values approximately an order of magnitude above the mean, and were typically highest in large cities and along transportation corridors. Relative to RSEI, APBC and APLC were larger in certain regions including Los Angeles and New York City. Both varied with respect to race, ethnicity, and housing and exhibited significant spatial clustering.We developed novel AP metrics incorporating emissions from industrial facilities, along transportation corridors, and from power plants to characterize cancer-specific risks.Future research will use these metrics that represent multiple simultaneous sources of AP to identify specific constituents of the AP exposome relevant for breast cancer and lung cancer, informing strategies to reduce their incidence and disparities.
Cancer Epidemiology, Biomarkers & Prevention , résumé, 2026