Combination locoregional and systemic therapies in hepatocellular carcinoma
Cet article passe en revue les données existantes concernant les traitements systémiques et locorégionaux pour les carcinomes hépatocellulaires puis examine les résultats des études évaluant la combinaison de ces traitements
Locoregional therapies play a fundamental role in the treatment of patients with early and intermediate and locally advanced hepatocellular carcinomas. With encouraging recent advances in immunotherapy-based systemic therapies, locoregional therapies are being both promoted and challenged by new systemic therapy options. Combined locoregional and systemic therapies might enhance treatment outcomes compared with either option alone. This Series paper summarises the existing data on locoregional and systemic therapies for hepatocellular carcinoma, and discusses evidence from studies investigating their combination with a focus on their synergistic efficacy and safety.
The Lancet Gastroenterology & Hepatology , résumé, 2025