SynthSR: A public AI tool to turn heterogeneous clinical brain scans into high-resolution T1-weighted images for 3D morphometry
Cet article présente "SynthSR", une technique d'intelligence artificielle permettant de transformer tout type d'IRM cérébrale (quel que soit le contraste, l'orientation ou la résolution) en images T1 de haute résolution utilisables par tous les outils de neuro-imagerie
Every year, millions of brain magnetic resonance imaging (MRI) scans are acquired in hospitals across the world. These have the potential to revolutionize our understanding of many neurological diseases, but their morphometric analysis has not yet been possible due to their anisotropic resolution. We present an artificial intelligence technique, “SynthSR,” that takes clinical brain MRI scans with any MR contrast (T1, T2, etc.), orientation (axial/coronal/sagittal), and resolution and turns them into high-resolution T1 scans that are usable by virtually all existing human neuroimaging tools. We present results on segmentation, registration, and atlasing of >10,000 scans of controls and patients with brain tumors, strokes, and Alzheimer’s disease. SynthSR yields morphometric results that are very highly correlated with what one would have obtained with high-resolution T1 scans. SynthSR allows sample sizes that have the potential to overcome the power limitations of prospective research studies and shed new light on the healthy and diseased human brain. A public AI tool turns clinical brain MRI of any resolution/contrast into 1mm T1 scans compatible with neuroimaging pipelines.
Science Advances , article en libre accès, 2022