Bigger May Not Be Better—Implications of Long-term Results From KLASS-02
Menée à partir des données d'un essai randomisé incluant 1 050 patients atteints d'un cancer gastrique localement avancé (âge moyen : 60 ans), cette étude compare l'efficacité à long terme, du point de vue de la survie globale et de la survie sans récidive à 5 ans, d'une gastrectomie par voie ouverte et par voie laparoscopique
We read with great interest the recent article by Son and colleagues presenting 5-year updates from Korean Laparoendoscopic Gastrointestinal Surgery Study-02 (KLASS-02), a noninferiority phase 3 trial that randomized 1050 patients with cT2-T4aN0-1M0 gastric cancer to laparoscopic or open distal gastrectomy. The investigators previously reported that laparoscopic distal gastrectomy was noninferior regarding the primary end point of 3-year recurrence-free survival, and now show that 5-year overall survival is also similar, but that long-term morbidity is significantly lower in the laparoscopic group.
JAMA Surgery , éditorial en libre accès, 2021