Do Breast Cancer Risk Scores Work for You?
Menée à partir de données génétiques portant sur 19 434 femmes d'origine africaine atteintes ou non d'un cancer du sein (9 241 cas de cancer et 10 193 témoins), cette étude évalue l'association entre des scores polygéniques (PRS-179 et PRS-313) et le risque de cancer du sein
Polygenic risk scores (PRS) realizepersonalized medicine by aggregating the marginal effects of genetic variants across the genome to identify individuals at high risk of developing common diseases, such as cancer,cardiovasculardisease, diabetes, etc.In theory, predicting risk from PRS isa minimally invasive strategy for prioritizing high risk individuals towardsearly screening and intervention where available.
Journal of the National Cancer Institute , commentaire en libre accès, 2020