How best to treat older patients with metastatic colorectal cancer?
Mené sur 160 patients atteints d'un cancer colorectal métastatique (âge médian : 78 ans), cet essai de phase II évalue l'efficacité, du point de vue de la survie sans progression, la toxicité d'une chimiothérapie combinant des doses réduites de S-1 et d'oxaliplatine par rapport à une monothérapie de S-1 à doses normales
More than 50% of cases of metastatic colorectal cancer in western countries occur in patients older than 65 years of age. However, although a PubMed search for the terms “colorectal cancer” and “elderly” yields more than 4000 published articles for every year since 2013, very few prospective controlled trials have been done in this patient population
The Lancet Gastroenterology & Hepatology , commentaire, 2018