The cancer epigenome: Concepts, challenges, and therapeutic opportunities
Ce dossier présente un ensemble d'articles sur les avancées récentes en matière de stratégies thérapeutiques anticancéreuses : réduction des doses administrées, inhibiteurs de PARP, traitements ciblant les systèmes de régulation épigénétique, déchets cellulaires responsables de la cancérogenèse ou oncogènes RAS
Cancer biology is profoundly influenced by changes in the epigenome. Because the dynamic plasticity of the epigenome lends itself well to therapeutic manipulation, the past few years have witnessed an unprecedented investment in the development, characterization, and translation of targeted epigenetic therapies. In this review, I provide a broad context for recent developments that offer a greater understanding of how epigenetic regulators facilitate the initiation, maintenance, and evolution of cancer. I discuss newly developed epigenetic therapies and the cellular and molecular mechanisms that may govern sensitivity and resistance to these agents. I also review the rationale for future combination therapies involving existing and emerging epigenetic drugs.
Science , résumé, 2016