Trabectedin: adding clarification rather than novelty
Mené au Japon sur 76 patients atteints d'un sarcome de stade avancé relié à une translocation, cet essai de phase II évalue l'efficacité, du point de vue de la survie sans progression, et la toxicité de la trabectédine en traitement de deuxième ligne
Therapy for soft-tissue sarcoma typifies the refinement of treatment of solid tumours through molecular pathology. After registration of imatinib for gastrointestinal stromal tumour, the murine compound trabectedin was introduced as another targeted agent in sarcoma. The drug mainly showed activity in myxoid liposarcoma characterised by a FUS-CHOP or DDIT3-CHOP translocation. Its radiological response pattern resembles that of tyrosine kinase inhibitor treatment in gastrointestinal stromal tumour.
The Lancet Oncology , commentaire, 2014