Physical function as a prognostic biomarker among cancer survivors
Menée sur 413 patients ayant survécu à un cancer (durée médiane de suivi : 11 ans), cette étude évalue l'association entre des mesures objectives de leur niveau de performance physique (vitesse de la marche, score obtenu aux tests du Short Physical Performance Battery, ...) et la mortalité
Background : We tested the hypothesis that objectively measured physical function predicts mortality among cancer survivors.
Methods : We assessed objectively measured physical function including the short physical performance battery (SPPB) and fast walk speed in older adult cancer survivors.
Results : Among 413 cancer survivors, 315 (76%) died during a median follow-up of 11.0 years. In multivariable-adjusted analyses, each 1-unit increase in the SPPB score and 0.1 m s−1 increase in fast walk speed predicted a 12% reduction in mortality (hazard ratio (HR): 0.88 (95% confidence interval (CI): 0.82–0.94); P<0.001, and HR: 0.88 (95% CI: 0.82–0.96); P=0.003, respectively).
Conclusions : Objectively measured physical function may predict mortality among cancer survivors.
British Journal of Cancer , résumé, 2013