The optimum duration of front-line chemotherapy
A partir d'une revue de la littérature (5 essais identifiés, ayant inclus au total 1 139 patients atteints d'un cancer avancé du poumon non à petites cellules), cette méta-analyse compare l'efficacité, du point de vue de la survie globale et de la survie sans progression, et la toxicité de six cycles de chimiothérapie à base de sels de platine par rapport à un plus petit nombre de cycles
Platinum-based chemotherapy represents the cornerstone of first-line treatment of advanced non-small-cell-lung cancer, but the optimum duration of therapy remains unclear. In practice, an initial response after two or three chemotherapy cycles is typically followed by a plateau in response, despite the administration of additional treatment. Whether this plateau is related to chemotherapy or to the biological background of the tumour cells is unknown. To draw reliable conclusions is difficult be ...
The Lancet Oncology , commentaire, 2013