From Cancer Genomics to Precision Oncology—Tissue’s Still an Issue
Cet article analyse les perspectives offertes par une classification des tumeurs à partir d'informations génomiques pour remplacer, dans le cadre d'essais cliniques, la classification basée sur la localisation anatomique
Rapidly evolving genome technology has enabled extensive molecular analysis of limited tumor biopsy material, thereby facilitating the broader implementation of personalized cancer medicine. However, genomics-based patient stratification across diverse tumor types is unlikely to supplant tissue-of-origin considerations in addressing clinical needs, including the development and application of novel "rationally targeted" cancer therapies.
Cell , résumé, 2013