Limited-Stage Hodgkin Lymphoma: Managing Uncertainty
Mené sur 1 137 patients atteints d'un lymphome hodgkinien de stade I/II et ayant subi, après deux cycles de chimiothérapie de type ABVD, une tomographie numérique par émission de positrons dont le résultat ne révèle pas d'envahissement ganglionnaire (âge : 15 à 70 ans), cet essai met en évidence une association entre l'absence de radiothérapie post-traitement et un risque accru de récidive précoce
In 1991, an editorial written by Hoppe was published in Journal of Clinical Oncology that discussed uncertainties associated with optimum management of patients with early-stage Hodgkin lymphoma; the editorial was entitled “A Choice of Treatments or a Treatment of Choice?” The editorial addressed the role of staging laparotomy to define patient-specific treatment, whether preferred management was with radiation therapy and/or chemotherapy and, within these choices, the details of the radiation treatment prescriptions and chem-
otherapy regimens. Considerable new evidence has been obtained since Hoppe’s 1991 editorial, and cure rates with initial therapy have improved from his descriptions of 75% to almost 90%. However, debates continue about fundamental management choices, including the role of radiation therapy and whether determinants exist that permit patient-specific decisions...
Journal of Clinical Oncology , éditorial en libre accès, 2014