Discovery and Exploitation of Novel Targets by Approved Drugs
Mené sur 29 patients atteints d'un carcinome basocellulaire, cet essai de phase II évalue l'activité antitumorale et la toxicité d'un antifongique inhibiteur de la signalisation Hedgehog, l'itraconazole
The Hedgehog (Hh) signaling pathway is essential for the development of multicellular organisms. Given that this pathway controls a number of key developmental processes, it comes as no surprise that several congenital malformations are caused by genetic alterations in the Hh pathway.1 Hh signaling is primarily critically active at the developmental stage, less so in adult life.
Journal of Clinical Oncology , éditorial en libre accès, 2014