Location, Location, Location: Macrophage Positioning within Tumors Determines Pro- or Antitumor Activity
Menée à l'aide de modèles murins, cette étude met en évidence le rôle joué par la signalisation des protéines Sema3A et Nrp1 dans la localisation des macrophages associés aux tumeurs et leur fonction tumorigénique
Macrophages infiltrate hypoxic tumor regions, where they promote angiogenesis and immunosuppression. In this issue of Cancer Cell, Casazza and colleagues report that tumor-associated macrophage (TAM) entry into avascular tumor areas is regulated by Semaphorin 3A/Neuropilin-1 signaling; interference with this pathway entraps TAMs in oxygenated areas, preventing their tumorigenic function.
Cancer cell , commentaire, 2012