New Technique Allows Anti-Breast Cancer Drugs to Cross Blood-Brain Barrier
Menée à l'aide de modèles murins, cette étude évalue l'intérêt d'une nouvelle approche visant à rendre perméable la barrière hémato-encéphalique pour faciliter la détection de micro-métastases et l'accès des agents chimiothérapeutiques aux sites des métastases cérébrales
Some breast cancer drugs can penetrate the blood-brain barrier (BBB), but they have not been very effective against brain metastases, whereas other, more effective anti-breast cancer drugs cannot penetrate the BBB at all. In a study published October 9 in the Journal of the National Cancer Institute, researchers used a new approach to selectively permeabilize the BBB at sites of brain metastases, even those 200 times smaller than currently detectable in the clinic...
Journal of the National Cancer Institute , communiqué de presse, 2013