RASAL2: Wrestling in the Combat of Ras Activation
Menée à l'aide de modèles murins, cette étude met en évidence des mécanismes par lesquels le gène RASAL2 joue un rôle de suppresseur de tumeurs et de métastases
Oncogenic activation of Ras proteins due to missense mutations is frequently detected in human cancers but rarely in breast cancer. In this issue of Cancer Cell, McLaughlin and colleagues report that ablation of the GasGAP gene, RASAL2, is an alternative mechanism by which Ras becomes activated in breast cancer.
Cancer cell , commentaire, 2012