The search for alternative androgen-deprivation therapies
Mené sur 254 patients atteints d'un cancer de la prostate de stade localement avancé ou métastatique, cet essai de phase II compare, du point de vue de la morbidité et de la mortalité cardiovasculaire, deux traitements hormonaux, l'un à l'aide d'estrogènes administrés par patch, l'autre à l'aide d'agonistes de la LH-RH administrés par voie orale
Since the 1940s, when the hormone-dependent nature of prostate cancer was first reported, finding alternatives to surgical castration has been an active area of research. Even with its side-effects, androgen-deprivation therapy (ADT) remains central to the treatment of advanced prostate cancer. Although ADT was first indicated for metastatic prostate cancer, use of this approach before distant metastases are seen improves overall survival, and early treatment has become widespread...
The Lancet Oncology , commentaire en libre accès, 2012