The Akt DUBbed InAktive
Menée in vitro et à l'aide de xénogreffes, cette étude met en évidence le rôle joué par des cycles d'ubiquitination et de déubiquitination du gène Akt dans la croissance de tumeurs du cancer de la prostate
Akt is a central node in the phosphoinositide-3 kinase–Akt–mammalian target of rapamycin pathway and is activated by a multistep process in response to growth factor stimulation. An additional layer of posttranslational modification has emerged as a new paradigm in the regulation of Akt. The identification of an E3 ligase for Lys63-linked ubiquitination of Akt has now been complemented with the discovery of the tumor suppressor cylindromatosis as a deubiquitinating enzyme (DUB) for Akt. Thus, like phosphorylation and dephosphorylation, cycles of ubiquitination and deubiquitination provide additional on-off switches that keep Akt activity in balance, and disturbances in this balance have pathological consequences.
Science Signaling , commentaire, 2013