A Missing Link in Genotype-Directed Cancer Therapy
Cet article plaide pour la mise en place d'un inventaire exhaustif des circuits de rétroaction entre voies de signalisation à l'œuvre au sein des cellules cancéreuses
Genotype-directed therapy holds great promise for the treatment of cancer, but crosstalk between signaling pathways often confounds simple genotype-drug response relationships. To deliver on the promise of precision medicine, a coordinated effort is needed to make a comprehensive inventory of the many signaling feedback circuits that exist in cancer cells.
Cell , résumé, 2011