Treatment for plexiform neurofibromas in patients with NF1
Mené sur 36 patients atteints de neurofibromes plexiformes, cet essai de phase II évalue l'efficacité de l'imatinib pour réduire le volume des tumeurs
Plexiform neurofibromas are congenital lesions associated with neurofibromatosis type 1 (NF1). They grow at variable rates, particularly in childhood, and can result in substantial morbidity and early mortality. Tumours can be multiple and extensive, and cause differing symptoms depending on their location, including pain and disfigurement, functional impairment of vision, mobility, bladder and bowel function, and respiratory compromise...
The Lancet Oncology , commentaire en libre accès, 2011