The Not-so-Skinny on Muscle Cancer
Menée à l'aide d'un modèle murin, cette étude met en évidence un mécanisme par lequel des adipocytes peuvent induire la formation d'un rhabdomyosarcome
The childhood cancer embryonal rhabdomyosarcoma can arise in tissue without skeletal muscle elements. In this issue of Cancer Cell, Hatley and colleagues report that non-skeletal muscle progenitors can be a cell of origin for Sonic Hedgehog-driven embryonal rhabdomyosarcoma in an adipocyte-restricted conditional mouse model.
Cancer cell , commentaire, 2011