Preoperative chemotherapy for colon cancer is getting closer
Mené sur 150 patients atteints d'un cancer du côlon de stade localement avancé, cet essai britannique évalue la faisabilité et la toxicité d'une chimiothérapie préopératoire
Postoperative chemotherapy is regarded as the gold standard of care for patients with colon cancer, who after surgical and pathological staging present as stage III or stage II with high risk factors. A combination of oxaliplatin and fluorouracil, whether given with folinic acid and in continuous infusion (FOLFOX4) or bolus (Roswell Park regimen), or with oral capecitabine, administered over 6 months showed improved outcomes over single agent folinic acid modulated fluorouracil...
The Lancet Oncology , commentaire, 2011