Biomarkers for screening, diagnosis and monitoring of ovarian cancer
Cet article fait le point sur les marqueurs tumoraux sériques couramment utilisés pour le dépistage, le diagnostic et la surveillance du cancer de l'ovaire et passe en revue les nouveaux biomarqueurs en cours d'étude et de validation
Serum tumor markers have a major role in the screening, diagnosis and monitoring of most gynecologic cancers. Ovarian cancer is one of the deadliest of the group because it is so frequently asymptomatic until it has advanced to an untreatable stage. Even CA 125, clinically one of the most reliable serum markers for ovarian cancer, is elevated in only half of early-stage still-treatable tumors. Because of the very low prevalence of ovarian cancer in the general population, at present there is no cost-effective imaging or simple microscopic screening test for ovarian cancer, as there is for breast and cervical cancers. However, recent proteomics and nucleic acid -based analyses have shown great promise for the discovery of new and more useful serum biomarkers, that cumulatively might provide such a screening tool. In this review we will discuss both the currently utilized serum tumor markers for screening, diagnosis, monitoring of ovarian cancer and the novel biomarkers that are now under investigation and validation.
Cancer Epidemiology Biomarkers & Prevention , résumé, 2012