Issues to be considered when studying cancer in vitro
Cet article passe en revue les limites des modèles expérimentaux et précliniques pour les recherches sur le cancer
Various cancer treatment approaches have shown promising results when tested preclinically. The results of clinical trials, however, are often disappointing. While searching for the reasons responsible for their failures, the relevance of experimental and preclinical models has to be taken into account. Possible factors that should be considered, including cell modifications during in vitro cultivation, lack of both the relevant interactions and the structural context in vitro have been summarized in the present review.
Critical Reviews in Oncology/Hematology , résumé, 2011