Fragile Delivery to the Genome
Ces deux études mettent en évidence le rôle clé joué par la protéine MMS19 dans le métabolisme de l'ADN et le maintien de l'intégrité du génome
When an important, fragile package needs to be delivered with high assurance, a dependable envoy can ensure that it lands in the right hands. Iron-sulfur (Fe-S) clusters are one such package in the cell. Many proteins, including some that replicate and maintain the nuclear genome, require them. Two papers in this issue—by Gari et al. (1) on page 243 and Stehling et al. (2) on page 195—identify MMS19 as the envoy that delivers Fe-S clusters to enzymes that maintain genome integrity.
Science , commentaire, 2012