Resurrecting DNAzymes as Sequence-Specific Therapeutics
Menée sur un modèle murin de cancer de la peau, cette étude évalue l'activité antitumorale et la toxicité de Dz13, une enzyme ADN ciblant l'ARN messager c-jun
In a mouse model of skin cancer, intratumoral injection of a sequence-specific mRNA-cleaving DNA enzyme caused potent inhibition of tumor growth and unusually benign pharmacodynamic profiles.
Science Translational Medicine , commentaire, 2012