EGFR in Limbo
Menée à l'aide de simulations numériques, cette étude montre que des mutations du gène EGFR, en induisant un état stable de la kinase EGFR, favorisent son activation
The epidermal growth factor receptor (EGFR) is normally activated by ligand-induced dimerization. Oncogenic mutations in EGFR promote activation in a largely ligand-independent manner. Shan et al. uncover a partially disordered state of EGFR kinase, providing evidence that oncogenic mutations counteract this intrinsic structural instability to promote dimerization and aberrant activation.
Cell , commentaire, 2011