VEGF-D(ilated) Lymphatics as Gateways to Metastasis
Menée à l'aide de modèles murins, cette étude met en évidence un mécanisme par lequel le facteur de croissance VEGF-D favorise le processus métastatique
VEGF-C and VEGF-D have been implicated in lymphatic metastasis, mainly as inducers of new intra/peritumoral capillary lymphatics. In this issue of Cancer Cell, Karnezis and colleagues challenge this notion and demonstrate that tumor-derived VEGF-D promotes metastasis by causing prostaglandin-dependent dilation of collecting lymphatics outside of the tumor mass.
Cancer cell , commentaire, 2011