Cancer Biomarkers
Cet article passe en revue les principales étapes du développement de biomarqueurs en oncologie et, notamment, livre des recommandations pour la publication des résultats d'études dans ce domaine
Biomarkers have many potential applications in oncology, including risk assessment, screening, differential diagnosis, determination of prognosis, prediction of response to treatment, and monitoring of progression of disease. Because of the critical role that biomarkers play at all stages of disease, it is important that they undergo rigorous evaluation, including analytical validation, clinical validation, and assessment of clinical utility, prior to incorporation into routine clinical care. In this review we address key steps in the development of biomarkers, including ways to avoid introducing bias and guidelines to follow when reporting results of biomarker studies.
Molecular Oncology , résumé, 2011