Spheres without Influence: Dissociating In Vitro Self-Renewal from Tumorigenic Potential in Glioma
Menée sur un modèle murin de gliome, cette étude montre que la capacité d'auto-renouvellement des cellules tumorales n'est pas nécessairement associée à leur capacité de prolifération
The capacity for self-renewal is thought to be a critical property of tumor-initiating cells. This capacity is often associated with the ability to generate spheres in vitro. In this issue of Cancer Cell, Barrett et al. show that cells lacking sphere-forming ability can still be very efficient at propagating tumors.
Cancer cell , commentaire, 2011