Location, Location, Location: FoxM1 Mediates ²-Catenin Nuclear Translocation and Promotes Glioma Tumorigenesis
Menée in vitro, cette étude identifie un mécanisme impliquant la protéine FoxM1 dans la progression d'un glioblastome
Genetic alterations in the Wnt/²-catenin/TCF-signaling pathway are commonly found in human tumors, but not in glioblastomas. In this issue of Cancer Cell, Zhang et al. report that FoxM1 mediates ²-catenin nuclear translocation in glioblastoma, suggesting a novel mechanism for glioblastoma progression in the absence of conventional Wnt/²-catenin pathway activation.
Cancer cell , commentaire, 2010