The different roles of ER subtypes in cancer biology and therapy
Cet article passe en revue le rôle des différents sous-types de récepteurs aux estrogènes dans les cancers du sein hormono-dépendants
By eliciting distinct transcriptional responses, the oestrogen receptors (ERs) ER
α and ERβ exert opposite effects on cellular processes that include proliferation, apoptosis and migration and that differentially influence the development and the progression of cancer. Perturbation of ER subtype-specific expression has been detected in various types of cancer, and the differences in the expression of ERs are correlated with the clinical outcome. The changes in the bioavailability of ERs in tumours, together with their specific biological functions, promote the selective restoration of their activity as one of the major therapeutic approaches for hormone-dependent cancers.
Nature Reviews Cancer , résumé, 2010