Hypoxia and hyperglycaemia determine why some endometrial tumours fail to respond to metformin
Ce dossier présente une série d'articles concernant le métabolisme des cellules cancéreuses, notamment les processus métaboliques susceptibles de constituer des cibles thérapeutiques
High expression of Ki67, a proliferation marker, is associated with reduced endometrial cancer-specific survival. Pre-surgical metformin reduces tumour Ki-67 expression in some women with endometrial cancer. Metformin’s anti-cancer activity may relate to effects on cellular energy metabolism. Since tumour hypoxia and glucose availability are major cellular redox determinants, we evaluated their role in endometrial cancer response to metformin.
British Journal of Cancer , article en libre accès, 2019