Vitamin B6 Intake and Pancreatic Carcinoma Risk: A Meta-Analysis
A partir d'une revue systématique de la littérature (9 études), cette méta-analyse évalue l'effet d'une supplémentation en vitamine B6 sur le risque de cancer du pancréas
Objectives : There are conflicting results for the association between vitamin B6 intake with reduced pancreatic carcinoma risk. Thus, a meta-analysis was performed to summarize the evidences from epidemiological studies.
Methods : We searched documents from PubMed-Medline, Web of Science, and Cochrane Library. The results were analyzed by using Stata software.
Results : A total of nine studies were included. The multivariate-adjusted results found that the total RR values of pancreatic carcinoma was 0.65 (95% CI: 0.53?0.80) for the highest vitamin B6 intake vs the lowest vitamin B6 intake, and there was no significant heterogeneity among studies (I2?=?42.0%, P?=?0.087). Sensitivity analysis indicated that no single study leaded to an excessive change for the relation between vitamin B6 intake and pancreatic carcinoma risk.
Conclusions : This meta-analysis suggested that vitamin B6 intake could significantly decrease pancreatic carcinoma risk. However, further study is needed based on the limitations of the current analysis.
Nutrition and Cancer , résumé, 2018