A new standard for malignant pleural mesothelioma
Mené en France sur 448 patients atteints d'un mésothéliome pleural malin de stade avancé, cet essai randomisé de phase III évalue l'efficacité, du point de vue de la survie globale, et la toxicité de l'ajout de bévacizumab à un traitement de première ligne combinant cisplatine et pémétrexed
Mesothelioma is an asbestos-related malignancy that begins in the pleural lining of the lung, pericardium, peritoneum, or testes. Early-stage pleural mesothelioma can be resected, but almost always recurs. Many patients are diagnosed at an advanced stage of disease, at which point surgery has no role. Since 2003, the standard treatment for unresectable disease has been combination chemotherapy with cisplatin and pemetrexed. Despite many attempts, until now, no regimen has further improved survival.
The Lancet , commentaire, 2014