Proteostasis trumps YAP in colon cancer
Menée in vitro et in vivo sur des modèles de cancer colorectal, cette étude met en évidence des mécanismes par lesquels la vertéporfine, un agent photosensibilisant, réprime la prolifération des cellules cancéreuses
In this issue of Science Signaling, Zhang et al. find a new role for verteporfin in the control of colorectal cancer progression through the selective induction of proteotoxicity rather than through inhibition of the transcription cofactor YAP. The study further documents the potential strategy of targeting proteostasis to kill cancer cells.
Science Signaling , commentaire, 2014