The GLU that Holds Cancer Together: Targeting GLUtamine Transporters in Breast Cancer
Menée in vitro et in vivo, cette étude met en évidence des mécanismes par lesquels, via les protéines porteuses de la glutamine, la protéine RNF5 régule la réponse au paclitaxel des cellules de cancer du sein
Many cancer cells require exogenous glutamine for proliferation, supply of TCA cycle intermediates, lipid synthesis, mTOR activity, and neutralization of reactive oxygen species. In this issue of Cancer Cell, Jeon and colleagues identify chemotherapy-induced endoplasmic reticulum stress as a novel strategy to target glutamine dependence.
Cancer Cell , commentaire, 2014