Vascular-Promoting Therapy Reduced Tumor Growth and Progression by Improving Chemotherapy Efficacy
Menée à l'aide de modèles murins, cette étude met en évidence des mécanismes par lesquels, en augmentant l'angiogenèse tumorale, le cilengitide à faibles doses accroît l'efficacité antitumorale de la gemcitabine
In this issue of Cancer Cell, Wong and colleagues describe a novel approach of increasing the number of functional blood vessels in tumors using a low-dose therapy regimen of Cilengtide and Verapamil. This method enhanced Gemcitabine delivery, uptake, and metabolism within tumor cells to reduce tumor growth and progression.
Cancer Cell , commentaire, 2014