Effect of docetaxel on safety and efficacy of radium-223
Mené sur 921 patients atteints d'un cancer de la prostate résistant à la castration et présentant des métastases osseuses symptomatiques, cet essai de phase III évalue, en fonction de l'utilisation préalable ou non de docétaxel, l'efficacité, du point de vue de la survie globale, et la toxicité du dichlorure de radium 223 administré par voie intraveineuse
The landscape of prostate cancer is shifting. Within the past 5 years, there have been major advances in the understanding of the biology of prostate cancer, which have translated into improved overall survival for men with metastatic castration-resistant prostate cancer. This wave of chemotherapeutics, immunotherapy, androgen-receptor-directed drugs, and a radioisotope have brought new hope for patients and new questions for clinicians. In The Lancet Oncology , Peter Hoskin and colleagues rep ...
The Lancet Oncology , commentaire, 2013