Emerging Role of Radiopharmaceutical Therapy in Oncology: Advances, Challenges, and Future Directions
Cet article résume l'évolution des traitements radiopharmaceutiques, passe en revue les radioligands ciblant de nouvelles voies moléculaires, examine les stratégies visant à améliorer la réponse thérapeutique (notamment les associations avec les inhibiteurs de PARP et les immunothérapies) puis identifie les défis à relever pour optimiser la sélection des patients, standardiser la dosimétrie, lever la résistance thérapeutique et améliorer l'accès aux traitements
Radiopharmaceutical therapy (RPT) has transformed cancer management by enabling systemic delivery of ionizing radiation via molecularly targeted pharmaceutics, complementing external beam radiotherapy (EBRT), which primarily treats localized, radiographically defined lesions. By coupling diagnostic imaging with therapy, in a “radiotheranostic” paradigm, RPT supports patient-specific target selection, dosimetry and on-treatment monitoring. Progress in target discovery, radioligand chemistry and optimization of pharmacokinetics and biodistribution has improved efficacy and safety, culminating in FDA approvals of [177Lu]Lu-PSMA-617 (Pluvicto®) for metastatic castration-resistant prostate cancer (mCRPC) and [177Lu]Lu-DOTA-TATE (Lutathera®) for neuroendocrine tumors (NET). These successes highlight RPT’s expanding role across oncology. This review summarizes the evolution of RPT from early clinical milestones to modern regulatory approvals, then surveys emerging radioligands directed at new molecular pathways. We also discuss strategies to enhance therapeutic response including rational combinations with DNA damage response agents such as poly(ADP-ribose) polymerase inhibitors (PARPi) or immunotherapies. Finally, we outline key challenges such as optimal patient selection, dosimetry standardization, therapeutic resistance and access and highlight few ways to accelerate broader clinical integration and continued innovation.
JNCI Cancer Spectrum , article en libre accès, 2026