Sugar-Sweetened and Artificially Sweetened Beverages and Liver Cancer—A Hard Look at Soft Drinks
Menée à partir de données de 11 études portant au total sur 1 518 411 adultes (durée médiane de suivi : 17,8 ans ; 58,2 % de femmes), cette étude analyse l'association entre la consommation de boissons sucrées (édulcorées ou non) et le risque de cancer du foie par sous-type (2 811 cas dont 1 999 carcinomes hépatocellulaires et 444 cholangiocarcinomes intrahépatiques)
Liver cancer is a major public health concern in the US and across the world. In contrast to lung, colorectum, breast, and prostate cancers, liver cancer has a mortality rate that continues to increase and has become the third most common cause of cancer death globally. In the US, more than 30 000 people die from liver cancer annually. While the most common cause of liver cancer worldwide is chronic hepatitis B, the success of therapies for chronic viral hepatitides and the increasing rates of metabolic disorders, including metabolic dysfunction–associated steatotic liver disease (MASLD), have led to rapid changes in the epidemiology of liver cancer. By 2032, MASLD is estimated to become the second most common cause of liver cancer–related death in the US. However, cancer development is multifactorial; lifestyle, dietary, and dysmetabolic factors play key roles in disease risk and pathogenesis, regardless of primary underlying etiology.
JAMA Network Open , éditorial en libre accès, 2026