Proud about PRADA: radiotherapy before deep inferior epigastric perforator flap reconstruction
Mené au Royaume-Uni entre 2016 et 2017 sur 33 patientes atteintes d'un cancer du sein et nécessitant une mastectomie, cet essai multicentrique évalue la faisabilité d'une radiothérapie préopératoire suivie d'une mastectomie épargnant la peau et d'une reconstruction par lambeau cutanéo-graisseaux libre (DIEP)
In The Lancet Oncology, Paul Thiruchelvam and colleagues 1 report the findings of a prospective study (PRADA) that evaluated the safety and feasibility of skin-sparing mastectomy with axillary surgery and immediate autologous-based deep inferior epigastric perforator (DIEP) flap reconstruction after preoperative radiotherapy for patients with breast cancer. Over a period of almost 2 years, 33 patients were enrolled at two centres in the UK. The primary endpoint was the rate of open breast wounds greater than 1 cm requiring dressing or packing at 4 weeks after surgery. Secondary outcomes included the presence of an open breast wound at 8 and 12 weeks after surgery, DIEP flap failure rate, and patient-reported satisfaction with the breast reconstruction.
The Lancet Oncology , commentaire, 2021