Macrophage-tumor cell intertwine drives the transition into a mesenchymal-like cellular state of glioblastoma
Menée in vitro et in vivo, cette étude met en évidence un mécanisme par lequel les interactions entre les macrophages et les cellules de glioblastome favorisent la transition de ces cellules vers un état cellulaire de type mésenchymateux
Macrophages are the major non-neoplastic infiltrates in the glioblastoma microenvironment. In this issue of Cancer Cell, Hara et al. (2021) demonstrate that macrophages induce a transition of glioblastoma cells into the mesenchymal-like cellular state associated with an increased mesenchymal program in macrophages themselves and enhanced cytotoxicity of T cells.
Cancer Cell , commentaire, 2020