Pancreatic cancer is suppressed by fibroblast-derived collagen I
Menée à l'aide d'un modèle murin d'adénocarcinome canalaire du pancréas, cette étude démontre que la délétion du gène du collagène de type 1 dans les myofibroblastes exprimant l'actine alpha-SMA favorise l'immunosuppression et accélère la progression tumorale
Clinical implementation of anti-stromal therapies in pancreatic cancer has been delayed by unanticipated tumor-restraining properties of the desmoplastic stroma. In confronting these challenges, Chen et al. demonstrate in this issue of Cancer Cell that fibroblast-specific deletion of collagen I, in the background of oncogenic Kras-induced spontaneous murine pancreatic ductal adenocarcinoma, enhances immune suppression and accelerates progression of disease.
Cancer Cell , commentaire, 2020