Should Women at Lower-Than-Average Risk of Breast Cancer Undergo Less Frequent Screening?
Menée à l'aide de modèles de microsimulation, cette étude estime, en fonction de la densité mammaire, le nombre d'années de vie gagnées ainsi que le taux de faux-positifs, de biopsies non nécessaires et de surdiagnostic associés à deux stratégies de dépistage du cancer du sein (biennale, triennale) chez les femmes âgées de 50 à 74 ans et présentant un risque inférieur à la moyenne de développer la maladie
Mammography screening lowers a woman’s risk of dying from breast cancer by approximately 19% (1). As for any relative risk reduction, the absolute risk reduction varies based on a woman’s risk of developing breast cancer. Because the harms of mammography screening (specifically, false-positive results and overdiagnosis) vary less consistently by breast cancer risk level, the ratio of benefits to harms is more favorable for higher-risk women compared with those at low or average risk of breast cancer (2). With growing recognition of how mammography’s net benefit relates to individuals’ risk, the concept of risk-based breast cancer screening has grown more accepted and is being studied in a number of settings (3).
Journal of the National Cancer Institute , commentaire en libre accès, 2020